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1. Using what you know about the molecular structure of biofilms and explain with specific examples...

1. Using what you know about the molecular structure of biofilms and explain with specific examples how you think biofilms play a role in pathogenesis and protecting microbes from cleaning agents or drugs like antibiotics. Consider in your answer the solubility and chemical properties of carbohydrates.

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Answer #1

Biofilms: It is defined as surface-attached microbial communities that are composed of microorganisms and a matrix of extracellular polymeric substances (exopolysaccharides, proteins, lipids and nucleic acids)

Biofilm-related infections:

Biofilms are involved in numerous human diseases:

1. Cystic fibrosis patients often have Pseudomonas aeruginosa infections that often resistant to antibiotic treatment

2. Infections due to contaminated in-dwelling medical devices (eg: urinary catheters and hip replacement) by staphyloccus aureus.

3. gum diseases: by eg: streptoccoccus mutans.

Bacteria growing in a bofilm are highly resistant to antimicrobial treatments ( eg: antibiotics, chlorine)

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