Question

Mad cow disease:

Identify each protein and structural changes that makes it grow and the defect it has

Answer 1

PrP^Sc (scrapie isoform of the prion protein) prions are the infectious agent that causes diseases such as Creutzfeldt–Jakob disease in humans, bovine spongiform encephalopathy (mad cow disease) in cattle.

PrP^Sc is an alternatively folded variant of the cellular prion protein, PrP^C, which is a regular, GPI-anchored protein that is present on the cell surface of neurons and other cell types.

it is a four-ring -solenoid with short -strands connected by loops.