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A researcher administers Sarin, which is known to block the effects of acetylcholinesterase. How would this...

A researcher administers Sarin, which is known to block the effects of acetylcholinesterase. How would this affect the following?:

A. Acetylcholine levels in the synaptic cleft?

B. Acetylcholine levels in the presynaptic terminal?

C. Acetylcholine levels in the postsynaptic cell?

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Answer:

A researcher administers Sarin, which is known to block the effects of acetylcholinesterase. How would this affect the following?:

A. Acetylcholine levels in the synaptic cleft?

  • Since Acetylcholinesterase will be inhibited due to Sarin, therefore, Acetylcholine will remain in the synaptic cleft (build-up in concentration) and will cause continuous stimulation (increased depolarization and contraction) of muscles leading to paralysis.

B. Acetylcholine levels in the presynaptic terminal?

  • Due to feedback control, acetylcholine levels in the presynaptic terminal will decrease.

C. Acetylcholine levels in the postsynaptic cell?

  • Build-up of ACh depolarizes the postsynaptic cell and renders it refractory to subsequent ACh release.
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