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Seborrheic keratosis is a rare hereditary skin condition caused by an autosomal dominant mutation. Affected people...

Seborrheic keratosis is a rare hereditary skin condition caused by an autosomal dominant mutation. Affected people have skin marked with a number of small, sharply margined, yellowish or brownish areas covered with a thin, greasy scale. An affected man, whose father also had keratosis but whose mother did not, marries a normal woman and they have four children.

A) What is the chance that all four are normal?

B) What is the chance that at least two of the four children will be affected?

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Answer #1

In an autosomal dominant disorder, the mutated gene is a dominant gene located on one of the nonsex chromosomes (autosomes). Only one mutated gene is required to be affected by this type of disorder. In this case the father having an autosomal dominant disorder, has a 50 percent chance of having an affected child with one mutated gene (dominant gene) and a 50 percent chance of having an unaffected child with two normal genes (recessive genes).

A) There are very less chances of all four to be normal ( 0 to 50%)

B) There is 50 % chance that at least two of the four children will be affected.

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