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What are the biggest flaws of Induced pluripotent stem cells (iPSCs)?

What are the biggest flaws of Induced pluripotent stem cells (iPSCs)?

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Biggest flaw of induced pluripotent stem cells is that it involves the use of retrovirus. The retroviral vectors used to insert the genetic material may randomly integrate into the genome of the host. This can lead to the formation of tumors. The c-Myc gene that is commonly used in reprogramming, is an oncogene and its overexpression can lead to development of cancer.

The efficiency of reprogramming induced pluripotent stem cells from fibroblasts is very low, approximately 0.2%.

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