What is meant by the term heteroduplex DNA?
Check all that apply.
A) Heteroduplex DNA is a single-stranded DNA. |
B) Heteroduplex DNA is usually considered to be generated by DNA replication. |
C) Heteroduplex DNA is a double-stranded DNA duplex that usually contains small sequence variations or mismatched base pairs. |
D) Heteroduplex DNA is usually considered to be generated by pairing or annealing of two homologous DNA strands. |
E) Heteroduplex DNA is a double-stranded DNA duplex that usually does not contain sequence variations or mismatched base pairs. |
Answer:
C) Heteroduplex DNA is a double-stranded DNA duplex that usually contains small sequence variations or mismatched base pairs.
D) Heteroduplex DNA is usually considered to be generated by pairing or annealing of two homologous DNA strands.
Explanation:
Heteroduplex DNA is a double-stranded (duplex) molecule of nucleic acid originated through the genetic recombination of single complementary strands derived from different sources, such as from different homologous chromosomes or even from different organisms.
DNA annealing may occur spontaneously, but it is promoted in vivo by certain classes of annealingproteins. Three-stranded reactions yielding heteroduplex DNA proceed by a different mechanism referred to as DNA pairing, strand invasion, or strand exchange.
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