Question

The author’s state that “IFNg may serve as an EBOV antiviral therapy”. Do you agree with...

The author’s state that “IFNg may serve as an EBOV antiviral therapy”. Do you agree with this? Does the evidence the authors present justify this conclusion? Why or why not? Please list specific reasons and make sure that at least one of your reasons is not already stated within the article.

http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1005263

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IFNg may serve as an EBOV antiviral therapy. The authors present several line of evidence in support of their claim. They have shown that the IFNg blocs the EBOV infection of primary macrophages. The IFNg also decreased the infection of EBOV in dose dependent manner in mice. The IFNg changes the RNA expression profile. The authrs have also identified the human macrophage gene to identify the IFNg stimutated gene and found that these genes inhibit the EBOV infections. The direct injection of mice with IFNg into the mice helped them to surive the challenge of EBOV.

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