Question

1. Are organ transplants more susceptible to the body’s cell-mediated response or antibody-mediated response?Please explain.

2. given that proteins are manufactured by ribosomes and (in eukaryotes) are often subsequently dumped into the lumen of the rough endoplasmic reticulum (e.r.), what problems might transmembrane proteins present in terms of shuttling them to their appropriate location? In other words, what can cells do to ensure that nascent hydroPHOBIC proteins make it to their final destination in a largely hydrophilic environment?

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Answer 1

1. Organ transplantation refers to the transfer of organs from the body of one individual to the other. They are much more succeptible to the antibody mediated response. This is followed by destruction of the grafted organ by an adaptive immune response which involves the recognition of the foreign proteins followed by its destruction. The immune response is triggered by CD8 T cells or CD4 T cells. In addition to this, antibodies also contribute to the organ rejection. Difference in the Major Histocompatibility Complex between the donor and the recipient produces alloreactive response; it is directed against the allogenic MHC molecules present on the grafted molecule; followed by the intervention of the T cells and is subsequently rejected.