Question

Order the following events describing production of a membrane glycoprotein via the secretory pathway (use a., b., c. etc.):

a. The protein has a carbohydrate chemical addition added (glycosylation).

b. The secretory vesicle arrives at and fuses with the plasma membrane.

c. The RNA transcript is transported from the nucleus to the cytoplasm.

d. The protein leaves the ER membrane and reaches the Golgi complex.

e. The RNA message associates with a ribosome and synthesis begins.

f. The translating ribosome binds to the ER membrane.

g. The RNA is produced from a DNA gene.

Answer 1

Ans. g --------> c ---------> f ---------> e ----------> d -------------> a -------------> b

Explanation: For synthesis of there is syrhesis of mRNA from the template DNA sequence an dtheis mRNA is exported out of the necleus to cytoplasm. This mRNA at rough endoplasmic is bound by ribosmes to synthesize protein. This protein synthesized at rough endoplasmic reticulum is transported to golgi complex wherein protein is modified by addition of carbohydrate to form glycosylated protein. This glycosylated protein (glycoprotein) is transported via secretory vesicles towards the plasma membrane and integration of glycoprotein in the lipid bilayer in the plasma membrane.