Question

12) Referring back to the previous two questions, imagine that the MRCA was a known carrier for the recessive disorder PKU. What is the fold increase in risk of the offspring suffering from PKU for an offspring produced by two cousins vs. an offspring produced by one of these cousins and an unrelated individual in

          (a) Turkey

          (b) Europe

          (c) Japan

Note: Turkey's value is (1/50); Europe's (1/100); Japan's (3/1000)

Parent-offspring coef=(1/8)

Aunt-nephew coef=(1/8)

First cousins coef=(1/16)

Answer 1