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In some cases, a single amino acid substitution can cause a protein to lose its biological...

In some cases, a single amino acid substitution can cause a protein to lose its biological activity. In other cases, a single amino acid substitution causes no change to a protein's biological activity. Which statement can best be used as evidence to support an explanation for these observations

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Answer #1

The case where a single amino acid substitution changes the biological activity is called as non synonymous type of substitution. It may lead to incorporation of totally different amino acid or it may halt the protein systhesis. It is also called missense or nonsense mutation.

In the second case where the amino acid substitution is not affecting the biological activity is called silent mutation because of degeneracy property of genetic code which tells that a single amino acid can be incorporated by more than one type of codon.

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