Question

In celiac disease, a humoral response to gliadin occurs. This means that

CD8+ T cells attack cells with gliadin antigen on the surface.

CD4+ T cells attack cells with gliadin antigen on the surface

Antibody is made against gliadin antigens

NK cells attack gliadin

Answer 1

Option 3 is the correct answer.

Anti-gliadin antibodies are produced in response to gliadin, a prolamin found in wheat. In celiac disease  gluten elicits a mucosal inflammation that creates characteristic lesion of the small intestine. Infiltrates of plasma cells secreting gluten-specific IgA antibodies and autoantibodies to the enzyme transglutaminase 2 (TG2) are found in these lesions. Serum antibodies to gluten and TG2 are specific markers for celiac disease, and the antibody titers are highly predictive for disease development