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The antibodies produced in celiac disease are IgG and IgA. Which of the following processes had...

The antibodies produced in celiac disease are IgG and IgA. Which of the following processes had to happen for this to be true?

affinity maturation

somatic recombination

isotype switching

somatic hypermutation

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Answer #1

Celiac Disease is an autoimmune disorder in which the individuals own immune system attcks the small intestine when person takes Gluten diet.

Antigiladin antibodies (AGA), IgA and IgG are produced in Celiac disease by Isotype Switching

Isotype Switching is the mechansim which changes the B cell antibody production from one type to another type.

In this mechanism, the heavy chain of antibody is changed but the variable chain remain the same and so the class switching does not affect the antigen specificity

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