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helicobacter pylori can survive the acidic conditions of the human stomach and have been found to...

helicobacter pylori can survive the acidic conditions of the human stomach and have been found to cause the development of stomach _

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Helicobacter pylori can survive the acidic conditions of the human stomach and have been found to cause the development of stomach ulcers.

During infection, H.pylori attaches to epithelial cells and can either cause no response or initially (or sometimes after a while) cause an abnormal immune response that damages gastric mucosal barrier. When the gastric mucosal barrier is broken, HCl and pepsin begin to erode the mucosa. Acid stimulates the release of histamine from cells in the submucosa which then causes further acid release and so on. Acid also causes activation of pepsin from pepsinogen that damages mucosa. This lead to stomach ulceration.

H. pylori is also associated with gastritis, peptic ulcers(stomach ulcers), gastric adenocarcinomas and gastric MALT lymphomas.

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