Question

how a defect in apoptosis will affect the response to anticancer therapies.

Answer 1

Apoptosis ,also known as programmed cell death is a normal physiological and biochemical process that takes place in multicellular organism during which each cell undergoes changes and dies so that new cells are formed in its place to maintain a balance.Defects in apoptosis results in uncontrolled cell division and proliferation that leads to cancer.Oncogenic mutations are known to disrupt apoptosis and same mutations go on to reduce the treatment sensitivity of the anticancer therapies.A link between disruption of apoptosis during tumor development to de novo resistance and acquired drug resistance has been established from the studies on c-Myc-induced lymphomagenesis.