Question

Answer the question using the papers below (use the links below to access the corresponding articles)

Wang, Lili et al. 2011. SF3B1 and Other Novel Cancer Genes in Chronic Lymphocytic Leukemia. New England Journal of Medicine. 365:2497-2506. + supplementary material.
http://www.nejm.org/doi/full/10.1056/NEJMoa1109016

Nik-Zainal et al. 2016. Landscape of Somatic Mutations in 560 Breast Cancer Wholegenome sequences. Nature 534:47-54

https://www.ncbi.nlm.nih.gov/pubmed/27135926

7. (2pt.) Wang et al. list nine genes (Fig. 1). How many of these nine appear in Fig. 1b of Nik-Zainal et al.? The breast cancer list is obviously much more extensive, but do you think that chronic lymphocytic leukemia and breast cancer share the same set of genes prone to driver mutation?

Answer 1

Nine mutated genes at remarkable frequencies were identified, consisting four with accepted roles in chronic lymphocytic leukemia (TP53, ATM , MYD88, and NOTCH1) and five having unestablished roles (SF3B1, ZMYM3, MAPK1, FBXW7,and DDX3X). five genes appear in fig.1b that are MED23, FOXP1, MLLT4, XBP1, ZFP36L1.

The significant frequency in nine genes found in five main signaling pathways, where these genes play roles in Notch signaling (FBXW7 and NOTCH1 23), RNA splicing and processing (SF3B1 and DDX3X), DNA repair and control of cell-cycle (TP53 and ATM) and  inflammatory pathways (MYD88, DDX3X, and MAPK1). Therefore, we can say that chronic lymphocytic leukemia and breast cancer share the same set of genes prone to driver mutation.