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Which of the followings is true about gluconeogenesis? A. One ATP and one GTP is needed...

Which of the followings is true about gluconeogenesis?

A. One ATP and one GTP is needed to convert pyruvate to PEP

B. Oxaloacetate is involved in generating PEP

C. Primarily it occurs in the mitochondria

D. In occurs in the brain

multiple answers

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Homework Answers

Answer #1

A,B and C are correct

  • First reaction is the conversion of pyruvate to oxaloacetate catalyzed by pyruvate caboxylase. This reaction occurs in mitochondrial matrix.
  • Second reaction is the conversio of oxaloacetate to phosphoenol pyruvate catalyzed by PEP carboxykinase
  • This conversion of pyruvate to PEP requires 1GTP and 1ATP
  • The conversion of glucose-6-phosphate to glucose catalyzed by glucose-6-phosphatase, which is present in the membrane of ER of liver and kidney cells but is absent in muscle and brain
  • For this reason gluconeogenesis is not carried out in mauscle and brain
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