Question

Can you please explain, in the simplest terms possible, what the ZEB-1 gene does, it's mutation...

Can you please explain, in the simplest terms possible, what the ZEB-1 gene does, it's mutation type, and the phenotypes that can result? My teacher gave me this website for reference, but I can't understand anything that is on it. https://omim.org/entry/189909?search=zeb1&highlight=zeb1#geneFunction

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Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs.

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