Question

Describe what you think would happen, at the molecular level, if an organism had a mutation in its dynamin gene which resulted in a functionless dynamin protein?

Answer 1

Ans :-) Dynamin is a GTPase that plays a vital role in clathrin dependent endocytosis and other vesicular trafficking processes by acting as a pair of molecular scissors for newly formed vesicles originating from plasma membrane. Dynamin are important components of cleavage of clathrin coated vesicles, phagosomes and mitochondria. These protein help in organelle division, viral resistance and mitochondrial fusion.

Dysfunction and mutation in Dynamin have been implicated in pathophysiology of various disorders such as Alzheimer's disease, parkison's disease, Huntington 's disorder, heart failure, schizophrenia, cancer, epilepsy, osteoporosis, down' s syndrome etc.

If the Dynamin become non functional then Dynamin would not be able to perform all the above discussed functions and lead to disorders in human body.