Question

1. For Drug X, Cmax occurs at 4 hours post-dose, but maximum response does not occur until 8 hours post-dose. What would you expect to see on a hysteresis plot of concentration-response for this drug?

Group of answer choices

A. Counter-clockwise hysteresis

B. Uni-directional hysteresis

C. Clockwise Hysteresis

D. Bi-directional hysteresis

2.

A population pharmacokinetic model was developed using sparse pharmacokinetic data from two phase III studies. A method for evaluating this model’s performance on estimating the PK parameters is:

Group of answer choices

A. A plot of individual predicted vs. observed drug concentrations

B. Linear regression analysis

C. Manhattan plots

Answer 1

Question 1.) Answer is C.) Clockwise hysteresis because hysteresis is defined as dependence of state of a system on its history. Where the clockwise is when the effect decreaes with time for the given concentration. Counter clockwise means effect increaes for the drug with given concentration.

Question 2.) Answer is B.) Linear regression analysis because it is a linear approach to modelling relationship between scaler response (dependent) and the explanatory response (independent) variables. Factors has like weak exogenecity, independent, constant variance etc.

Thankyou..