Can the side-chain of glutamine make a bidentate interaction in the major groove at a G-U wobble base-pair in RNA? Explain your answer.
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Yes, according to wobbling hypothesis, the 3rd base in an mRNA codon can undergo non Watson-crick base pairing with the 1st base tRNA anticodon.
It can be because of, Hydrogen bond formation between the 3rd base on the condon and the 1st base on the anticodon can potentially occur in non Watson-crick manner. Therefore flexible base pairing occur at the 3rd position.
If G is at the 3rd position codon in the codon, it can base pair with C or U. If either of these is present at the 1st position in the anticodon.
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