Question

Adipose tissue requires high levels of NADPH for the synthesis of fatty acids (no need for...

Adipose tissue requires high levels of NADPH for the synthesis of fatty acids (no need for nucleotides or ATP). Considering glycolysis, gluconeogenesis and the pentose phosphate pathway, describe the flow of glucose 6-phosphate to address the needs of adipose tissue.

Science   Biology   
0 0
Add a commentTranscribed image text
Next >

Homework Answers

Answer #1

Glucose-6-phosphate is the starting material for the pentose phosphate pathway (PPP).

It generates 2 NADPH from one glucose-6-phosphate,

· One in the conversion of glucose-6-phosphate into 6-phosphogluconolactone.

· Another one in the conversion of 6-phosphogluconate into ribulose-5-phosphate.

These NADPH molecules are usually used for synthesis of fatty acids and nucleotides.

When fatty acid synthesis is happening in the adipose tissue, glycolysis is stopped and glucose-6-phosphate is directed to PPP to generate NADPH. If the glucose level is low, then gluconeogenesis would be activated to supply glucoe-6-phophate from various gluconeogenic molecules in order to generate more NADPH required for fatty acid synthesis.

0 0
Know the answer?
Your Answer:

Post as a guest

Your Name:

What's your source?

Earn Coins

Coins can be redeemed for fabulous gifts.

Log In

Sign Up

Not the answer you're looking for?
Ask your own homework help question
Similar Questions
Cancer cells do not respond normally to cues that regulate growth. As a result, cancerous cells...
Cancer cells do not respond normally to cues that regulate growth. As a result, cancerous cells grow and divide uncontrollably, requiring large amounts of nucleotides to support their high rate of nucleic acid synthesis and NADPH for the synthesis of fatty acids and for cell survival under stress conditions. Considering glycolysis, gluconeogenesis and the pentose phosphate pathway, describe the flow of glucose 6-phosphate to address the needs of cancerous cells.
An important feature of the regulation of glucose catabolism via glycolysis and the pentose pathway is...
An important feature of the regulation of glucose catabolism via glycolysis and the pentose pathway is reflected in the observation that: A. transaldolase and transketolase are isomers of fructose-1,6-diphosphate aldolase and pyruvate ketolase, respectively. B. regulation is primarily achieved by segregation of glucose catabolism via the glycolytic pathway in the cytosol and the pentose pathway in the mitochondria. C. unlike the glycolytic pathway, the pentose pathway is activated uniquely by high levels of NADPH. D. the catabolism of glucose via...
Under normal conditions, healthy heart cells (cardiac myocytes)prefer fatty acids as their fuel which ultimately results...
Under normal conditions, healthy heart cells (cardiac myocytes)prefer fatty acids as their fuel which ultimately results in energy being generated from oxidative phosphorylation through the electron transport chain. We will talk about how fatty acids are oxidatively metabolized in lecture 10. The condition ischemic cardiomyopathy is a result of narrowing of heart arteries which leads to decreased blood flow and a decrease in oxygen delivery to the muscle cells of the heart. In the ischemic heart, metabolism shifts from fatty...
6. Diabetic Ketoacidosis can occur in a patient with severely uncontrolled diabetes. Which of the following...
6. Diabetic Ketoacidosis can occur in a patient with severely uncontrolled diabetes. Which of the following is a key contributor to the acidosis? a. uncontrolled gluconeogenesis during the absorptive and post-absorptive state b. Increased liver glycogenesis during the absorptive state c.Decreased ketone body production in the liver during the post-absorptive state 7. Which of the following statements regarding Type 1 diabetics is true? a. Type 1 debiatics cannot produce insulin b. Type 1 diabetics are typically treated with insulin sensitizers...
MULTIPLE CHOICE 1. Many of the catabolic pathways converge to the common two-carbon intermediate: a. alanine....
MULTIPLE CHOICE 1. Many of the catabolic pathways converge to the common two-carbon intermediate: a. alanine. b. acetyl group of acetyl-CoA. c. lactic acid. d. glucose. e. carbon dioxide. 2. The lower (“energy payoff”) part of glycolysis: Only involves steps with DG close to zero, so it does not need to be regulated. Involves the formation of metabolites with high-energy phosphates. Involves enzymes that hydrolyse ATP to drive the pathway forward. Oxidises NADP+ to NADPH. 3. Gluconeogenesis begins with the...
Bioinformatics #4 1. What does the box labeled “INSR” refer to, and how many amino acids...
Bioinformatics #4 1. What does the box labeled “INSR” refer to, and how many amino acids are found in this protein? Insulin; 1382 Insulin receptor; 1382 Insulin; 4149 Insulin receptor; 4149 2. For INSR, the membrane-bound location of this protein is __________________, while the dephosphorylated form of this protein, the active (or sensitized) state, is indicated by the ____ symbol. a. indicated by the 2 thick parallel gray lines on the map; +p B. indicated by the 2 thick parallel...
BIOCHEMISTRY ASSIGNMENT Please use your understanding to address the few concerns below * Required Index Number:...
BIOCHEMISTRY ASSIGNMENT Please use your understanding to address the few concerns below * Required Index Number: * Your answer Program: Choose BSc Midwifery BSc Nursing Which of the diagrams illustrates the way in which the rate of an enzyme-controlled reaction depends on substrate concentration? * Captionless Image A B C D When starch and amylase are mixed in the presence of iodine solution, the blue-black colour rapidly disappears. This is due to the formation of which molecule? * glucose glycogen...
BIOCHEMISTRY ASSIGNMENT Please use your understanding to address the few concerns below * Required Index Number:...
BIOCHEMISTRY ASSIGNMENT Please use your understanding to address the few concerns below * Required Index Number: * Your answer Program: Choose BSc Midwifery BSc Nursing 1.When starch and amylase are mixed in the presence of iodine solution, the blue-black colour rapidly disappears. This is due to the formation of which molecule? * a) glucose b) glycogen c) sucrose d) maltose 2.Which of the following enzyme groups can catalyse oxidation reactions? * a) phosphorylases b) isomerases c) hydrolases d) dehydrogenases 3.Enzymes...
READ THE CASE STUDY AND ANSWER THE FOLLOWING QUESTIONS 2nd CASE: An Unexplained Death A 65-year-old...
READ THE CASE STUDY AND ANSWER THE FOLLOWING QUESTIONS 2nd CASE: An Unexplained Death A 65-year-old man of Scandinavian descent was rushed to the Emergency Room of your local hospital after a family member discovered him unconscious in his home. The woman who dialed “911” told the dispatcher that the man, her brother, was the local librarian of the past 10 years and had no spouse or children. She reported that they had spoken the day before, and he had...
1. Which of the following in not directly involved in the production of proteins? a. Golgi...
1. Which of the following in not directly involved in the production of proteins? a. Golgi complex b. Plasma membrane c. Rough endoplasmic reticulum d. Nucleus 2. A new coach tells his team that the reason they get fatigued after three minutes of exercise is because they do not have enough oxygen in their red blood cells. He has no data to support his position. Therefore his advice is? a. Valid since he is an expert working with people b....
ADVERTISEMENT
Need Online Homework Help?

Get Answers For Free
Most questions answered within 1 hours.

Ask a Question
ADVERTISEMENT