Question

Biochemistry

An allosteric effector is one that to an enzyme at a site other than the substrate binding site. In the case of hemoglobin allosteric effectors bind at a site other than the oxygen binding site. Which of the following is/are allosteric effectors?

	a.	H+
	b.	CO2
	c.	2,3- diphosphoglyceric acid
	d.	all of the above
	e.	none of the above

Answer 1

1. Answer: Option D is correct
Explanation:
An allosteric effector molecule binds to a protein at a site other than the active site and alters the rate of reaction.
Allosteric activators bind the protein and accelerate the rate of reaction by enhancing substrate binding or the catalytic process.
Allosteric inhibitors bind the protein and repress the rate of reaction by inhibiting substrate binding or the catalytic process.

Allosteric effectors of Hemoglobin:
1. H+
2. CO2
3. BPG (2, 3-Diphosphoglyceric acid)