Question

Scientists working in a lab were able to produce a cell that had defective kinetochore proteins which were unable to secrete a "wait signal" during cell division. Which description below would best describe the behavior of these cells due to this condition?

A)the cell line would become cancerous

B)mitosis would be frozen or stuck in metaphase

c)sister chromatids would nver be replicated

D)sister chromatids would separate independently from the other chromosomes

Answer 1

A is the answer.

Kinetochore is found on the centromere of the chromosome. It allows the spindle fibre to attach to it. And the chromosomes are arranged at the equatorial plate in metaphase by the process of congression.

The wait signal is secreted, when kinetochore is not attached to spindle fibre properly. Hence it inhibits the promotion of anaphase.

Now wait signal is not secreted. That's why the promotion of anaphase is not inhibited. The improper binding of kinetochore can even to the chromosome in the cell can also lead to promotion of anaphase. Hence there is found faster anaphase than normal cell. There is found non disjuction that leads to cancerous property.