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What different mechanisms do intracellular pathogens use to survive within the infected host cell.

What different mechanisms do intracellular pathogens use to survive within the infected host cell.

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Various pathogens utilize the intracellular compartment of the host as a niche for immune evasion and replication. The main pathway involved in intracellular survival of pathogens is when the bacteria are taken up by macrophages inside a phagosome. The pathogen including phagosome, however, is not able to combine with lysosomes and mature. no combination allows survival and growth of bacteria.

This is accomplished by:

  • destabilising endosomal trafficking.

  • reconstruction of the phagosome into a congenial vacuole.

  • supporting phagosomal membrane splitting and escaping to the cytosol.

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