Eukaryotes do not have Shine-Dalgaro sequences, so how does the eukaryotic ribosome recognise where to bind a mRNA in order for translation to start at the correct start codon?
Answere : Initiation of translation in
eukaryotes
There is no Shine-Dalgarno sequence in eukaryotes, instead they
have the small (40S) ribosomal subunit and initiation factors that
bind to 5' cap and that is why they have 5' cap. Poly(A) tail also
plays a role, once the small subunit is in place, the initiator
tRNA binds.
Kozak sequence is a sequence which occurs on eukaryotic mRNA and plays a major role in the initiation of the translation process.
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