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Major mechanisms of noncanonical Wnt/Planar Cell Polarity Pathway includes: a. B-catening in the nucleus b. Cytoskeletal...

Major mechanisms of noncanonical Wnt/Planar Cell Polarity Pathway includes:

a.

B-catening in the nucleus
b.

Cytoskeletal reorganization
c.

Inhibition of the destruction complex
d.

Proteosomal degredation
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Answer #1

Cytoskeletal reorganization

The Wnt signalling pathway is an ancient and evolutionarily conserved pathway that regulates crucial aspects of cell fate determination, cell migration, cell polarity, neural patterning and organogenesis during embryonic development.

The non-canonical pathway is often referred to as the β-catenin-independent pathway and this pathway can be further divided into two distinct branches, the Planar Cell Polarity pathway or PCP pathway and the Wnt/Ca2+ pathway. The planar cell polarity pathway is best known for its role in polarizing epithelial cells within the plane of tissue but it also plays a role in a range of cell migration events during development.

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