Question

Which of the following is TRUE for GPCR signalling? Select all that are true.

Select one or more:

a. GPCRs can form ion channels in some cases

b. GPCR acts as a GAP

c. signalling is the result of rearrangment of the transmembrane regions of the GPCR

d. Both the GPCR and the G protein can act as downstream signalling molecules

e. G protein acts as a GEF

Answer 1

Ans.

(c) singnalling is the result of rearrangement of the transmembrane regions of the GPCR

(d) both the GPCR and the G protein can act as downstream signalling molecules.

Explanation: GPRS ( G protein-coupled receptor) undergo confirmation change on perception of extracelluar signal, it transfers the signals through downstream signalling pathways inside the cell. G proteins are membrane bound protein involved in signal transduction from outside of the cell.