The hydropathy of an amino acid can be used to predict whether an amino acid side chain folds towards the inside or outside of a globular protein. Positive values are hydrophilic while negative values are hydrophobic.
True or false?
Hydropathy plot is a quantitative representation of hydrophilicity/hydrophobicity of amino acid stretches in a polypeptide chain. It is used to determine the membrane-spanning regions of proteins. Hydrophilic amino acids are located on the surface of a globular protein. Hydrophobic amino acids are buried inside the core of a globular protein.
Hydrophobic amino acids have a
positive hydropathy score.
Examples:
Ile = +4.5
Val = +4.2
Phe = +2.8
Hydrophilic amino acids have a
negative hydropathy score.
Examples:
Arg = -4.5
Lys = -3.9
Asn = -3.5
So, the given statement is incorrect.
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