Question

Do certain sequence contexts show a higher rate of de novo somatic mutation? Which sequence contexts, and what is the basis for this difference?

Answer 1

Yes, certain sequence contexts show de novo somatic mutations. Mostly the cancer forming cells are involved in somatic mutations where also leads to tumours. Generally the somatic mutations occur originally in a single cell. In the context of cancer, this arises into a tumour by the proliferation of thise cells. When comes to germline mutations where mutations occur in egg or sperm cells which are formed after fertilisation and inherited to childs. Other than germ cells are somatic cells also shows mutations. But mutations also occurs at fertilization before the first cell division and leads to denovo somatic mutation.