Question

In eukaryotic cells, when ribosomes are translating polypeptides they can be either free in the cytosol...

In eukaryotic cells, when ribosomes are translating polypeptides they can be either free in the cytosol or associated with endoplasmic reticulum (ER). What determines their location? a. Two types of ribosomes have different compositions that determine their location. b. The types of mRNA that ribosomes are translating determine their location c. The site of ribosomes assembly determines their location. d. Some stochastic events determine their location e. The polypeptide transport machinery determines their location on ER.?

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Answer #1

Answer - Option E. The polypeptide transport machinery determines their location on ER.

Explanation - There are two types of ribosomes, free and fixed. They are identical in structure but differ in locations within the cell. Free ribosomes are located in the cytosol and are able to move throughout the cell, whereas fixed ribosomes are attached to the rER. Free ribosomes synthesize proteins that are released into the cytosol and used within the cell. Fixed ribosomes synthesize proteins that are (1) inserted into the cell membrane at the rER and to their final destinations or (2) placed in membrane-bound vesicles and moved through the Golgi complex to the plasma membrane and released via exocytosis into the extracellular environment.

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