Question

How might a lipid storage disease differ from a disease involving the inability to make a structural lipid? (severity, symptoms, treatment)

Answer 1

Lipid storage disease is a metabolic disorder where higher amount of fatty acids accumulate in various cells and tissues in the body.
Gaucher disease
Deficiency of the enzyme glucocerebrosidase. Fats accumulated in brain, spleen, liver, kidneys, lungs, and bone marrow.

Symptoms
Brain damage, enlarged spleen and liver, liver malfunction, skeletal disorders and bone lesions.

Treatment
Enzyme replacement treatment given intravenously every two weeks.

Tay-Sachs disease
Deficiency in the enzyme hexosaminidase A.

Symptoms

Mental disability, dementia, decreased eye contact, loss of hearing , blindness etc

Treatment
Anticonvulsant medications may initially control seizures.
Proper nutrition and hydration.