Question

Explain how dominant negative mutation is different from heterozygous advantage

Answer 1

Dominant negative mutations also called the antimorphic mutations have an altered gene product which acts antagonistically to the wild-type allele. these mutations normally result in an altered molecular function that are often inactive and are characterised by a dominant or semi-dominant phenotype.

Whereas, heterozygote advantage describes the situation in which the heterozygous genotype has a higher relative fitness in comparision to the homozygous dominant or homozygous recessive genotype.The specific case in heterozygote advantage due to possesing of a single locus is known as overdominance.

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