Question

How would a deficiency in each of the following affect a person’s defenses of tissue and blood?

– Complement C3

– mannan-binding lectin (MBL)

– Polymorphonuclear leukocytes (PMNs)

– Macrophages

– Immunoglobulins

Answer 1

Deficiency of complement C3 results in systemic lupus erythematosus. This is an autoimmune disorder, where the healthy tissues of the body is attacked by own immune system.

mannan-binding lectin (MBL)- persons who have less amount of mannan-binding lectin (MBL) protein in their blood are mostly affected by infection of upper respiratory tract frequently.

Polymorphonuclear leukocytes (PMNs) are also called as granulocytes. The deficiency of Polymorphonuclear leukocytes (PMNs) will results in chances of getting infection quickly.

Macrophages are included in white blood cell which functions in engulfing cellular waste, foreign material, microbial organisms or cancer cell. Deficiency of macrophages will result inability to degrade foreign particle.

Immunoglobulins deficiency may cause repeated infection, autoimmune disease, or allergy.