Gene X encodes protein X, which normally functions as a transcription factor, regulating the expression of certain genes. A particular mutant allele of gene X is created by a frameshift mutation; the protein encoded by this mutation has kinase activity, meaning it acts as an enzyme that phosphorylates other proteins. This mutation is an example of
A. a gain-of-function mutation.
B. a loss-of-function mutation.
C. a neomorphic mutation.
A and C
B and C
A and C (a neomorphic mutation and a gain of new function mutation) is the answer.
It is given that protein X is reaponsible to transcription factor. It regulates the expression of genes via binding to the DNA.
Now, there is found frame shift mutation in such a way that this gene encodes a new protein which can phosphorylates other protein. Such proteins have kinase activity. In this way, there is found new function of this protein. Hence this is the case of neomorphic mutation or we can called it as a gain of function mutation.
A loss of function mutation leadd to reduce or abolish the function of genes.
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