Predict the sexual phenotype of a person who is XY but whose Y chromosome carries a deletion of the SRY gene. Explain your prediction.
Sex determining region Y (SRY) gene, also called as testis determining factor (TDF), is located on short arm of Y chromosomes (Yp11.3) in males. The gene is necessary for initiation of sex determination in males. Deletion or mutation in this gene will give rise to XY females (46, XY complete gonadal dysgenesis, CGD) having gonadal dysgenesis who give off an impression of being ordinary females during childbirth, however at adolescence do not develop secondary sexual characteristics, have amenorrhea, and fibrous gonads without eggs.
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