Question

TFIIH phosphorylates the CTD of RNA polymerase II at position #5 in the repeation heptapeptides. Which...

TFIIH phosphorylates the CTD of RNA polymerase II at position #5 in the repeation heptapeptides. Which amino acid is phosphoeylated during the process?

A) alanine

B) cysteine

C) threonine

D) serine

E) Glycine

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Answer #1

The hepatapeptides sequence which is present at the CTD tail of of RNA polymerase is Tyr-Ser-Pro-Thr-Ser-Pro-Ser(YSPTSPS). The N- terminal side of this sequence start from Tyr and from where numbering is started.so at the 5th position serine Amino acid is present. This phosphorylation by TFIIH helps in capping of the newly synthesis mRNA. you can refer to the given diagram.option D is correct.

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