Question

Which of the following would happen if a mutation knocked out the receptor for lysosome bound proteins in the golgi?

	A.	The proteins normally found in the lysosome would go to the mitochondria instead
	B.	The proteins normally found in the lysosome would accumulate in the golgi
	C.	The proteins normally found in the lysosome would accumulate in the Rough ER
	D.	The proteins normally found in the lysosome would go to the nuclear membrane instead

Answer 1

B is the answer.

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It is given that the receptor protein is mutated in the lysosome. That's why the lysosome tagged protein can not target to the lysosome. It will remain in the golgi body. Because of mutant receptor protein on lysosome, the protein can't interact with the receptor. Hence it remains in golgi body.

But the protein will remain bind to the wild type receptor present on lysosome. That's why the protein is found in lysosome in wild type cell. But it is found in golgi body in case of mutant type cell.