In studying the mechanism of serine proteases, scientists A and B introduce mutations into the enzymes and monitor the resulting enzyme activity. One
mutation changes the serine of the catalytic triad to cysteine. (10 points)
a. Scientist A thinks this mutation will increase the activity of the enzyme.
Briefly explain the reasoning behind scientist A’s hypothesis.
b. Scientist B thinks this mutation will reduce the activity of the enzyme.
Briefly explain the reasoning behind scientist B’s hypothesis.
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