Question

Describe 4 ways that epinephrine signaling pathway turn off?

Answer 1

After several seconds to minutes the G-protein actually undergo a self inactivationprocess through a water molecule from cytoplasm and hydrolyzes GTP to GDP. This leads to inhibit the activity of adenylate cycle prevent to form more cAMP.

Epinephrine bound to the receptor actually dissociates from its binding site. So, no ligand binding in the receptor leads to no activation of G-proteins.

Beta adrenergic receptor kinase phosphorylates the epinephrine-receptor complex leads to activate beta arrestin to bind to phosphorylated region. This prevent ligand-receptor complex from activated G-proteins.