Question

The polymerase that is making the leading strand

a) is connected to the polymerase that is making the lagging strand

b) should have a large processivity number

c) will likely have a 3' > 5' exonuclease

d) all of the above

Answer 1

ANSWER= d) all of the above

A) yes it is connected by t subunit in which replication complexes are joined

B) the processivity defined as the ability to proceed a reaction without releasing its substrate here, in this case, the substrate is DNA itself

• .the leading strand replicated without disassembly of the polymerase from DNA for a long time compare to polymerase of lagging strand.
• because both polymerases are connected so polymerase of lagging strand has to disassemble from DNA in order to synthesize DNA.

C) The polymerase has 3'>5' exonuclease activity which makes the removal of nucleotides which comes in the way.