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What are receptor tyrosine kinases? Discuss and provide an example.

What are receptor tyrosine kinases? Discuss and provide an example.

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These are essential component of signal transduction pathway which mediate cell to cell communication. these are present on cell surface. growth factor and hormones are signal molecule that bind to receptor tyrosine kinase. they contain intrinsic enzyme activity. the binding of signal molecule to RTK activate tyrosine kinase. for example insulin and IGF1 receptor expressed on cell surface as dimer. Binding of these receptor induce structural change in dimeric receptor which stimulate tyrosine kinase activity and cell signalling.

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