Question

Which of the following would NOT be an indicator of 'oxidative stress'

a. increased production of reactive oxygen species in mitochondria

b. a high ration of NADP+/NADPH

c. a high ratio of GSH/GSSG

d. high levels of oxidized glutathione in the cytosol

Answer 1

Oxidative stress = as the term itself tells it is the the state in which the antioxidants level in cells or tissues has been changed. This occurs due to The decrease in level of Oxygen creating stress conditions.

The redox status of cell or tissues changes. During Oxidative stress there is change in GSH/GSSG ratio and an increased ratio signifies stress. Ratio of redox couples like NADP+/ NADPH , NADH/NAD, lactate/Pyruvate, etc. Also changes and changes in these ratio also affect the energy ratio ATP/ADP+AMP. During Oxidative stress there is increase in Oxidised Glutathione and this changes the GSH/GSSG ratio.

So, accordingly the answer is Option A, increased production of Oxygen reactive species in Mitochondria is not an indicator of oxidative stress.