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What are two micro-scale methods by which the epigenome can alter phenotypic expression?

What are two micro-scale methods by which the epigenome can alter phenotypic expression?

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Epigenetic effects are those effects caused by chemical modifications to DNA that do not alter the DNA sequence but do alter the probability of gene transcription.

The phenotype-driven genetics methods of linkage analysis and positional cloning have enabled us to discover the genetic cause of mammalian Mendelian phenotypes, that is, those phenotypes with a perfect correspondence between phenotype and a single- locus genotype.

There are two types of epigenetic modifications - DNA methylation and histone modifications.

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