Question

Paternal imprinting of the Igf2r locus is established by differential methylation of DNA in the second intron of Igf2r. To study the biological function of Igf2r protein you generated cDNA of Igf2r. You then generated transgenic mice which have both alleles of the Igf2r locus replaced with the mutated Igf2r you generated. Which allele(s) of the mutated Igf2r are expected to be expressed?

A)   Maternal allele only   

B)Paternal allele only   

C)Both maternal and paternal alleles    

D) Neither the maternal nor the paternal allele

Answer 1