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42. Which of the following mutations would have the most dramatic and longest-lasting effect? Inactivation of...

42. Which of the following mutations would have the most dramatic and longest-lasting effect?

  1. Inactivation of DNA polymerase proofreading
  2. Inactivation of RNA polymerase proofreading
  3. Inactivation of Translational proofreading
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Answer #1

A is the right answer.

The DNA polymerase 3 is responsible for repairing the error prone base pairs. This enzyme repairs the mutated base present in DNA strand during DNA replication. If this enzyme is inactivated, then there is not found repairing of mutated base pair. This will be fixed in the DNA in the cell and mutated DNA pass to the generation.

This mutated base pair is leads to mutation in mRNA also. This will produce mutaed protein always. That's why it is most dramatic and has long lasting effect.

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