Question

There is a disease where the excess acetylcholine in the neuromuscular junction causes skeleton muscle spasms. Using what you know about neuromuscular electronic transduction and actin-based muscle contraction, describe ten strategies that the drug can be designed. (Will thumbs up answers)

Answer 1

The drug should decrease muscle tone as wel as pain

It should be spasmolyte

Should be neuro muscular blockers, they are of 2 types

a. Depolarize, which bind in acetyl choline receptor and act as agonist. Generates action potential)

b. Non depolarize, acts competitively antagonist in site of acetyl choline.

According to sliding filament theory, actin and myosin bind to create cross bridge and slides.

The medicine should enhance the process so as to get relief from muscle spasm.