Question

What effect would a mutation preventing the activity adenylate cyclase have on liver cells?

What effect would a mutation preventing the activity adenylate cyclase have on liver cells?

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Answer #1

In liver cell Adenylate cyclase enzyme converts ATP to Cyclic AMP. Cyclic AMP acts as secondary messanger inside cell. If a mutation occurs on liver cell which prevents the activity of adenylate cyclase,.it will not produce cyclic AMP which are responsible for glucose metabolism in liver. When C-AMP is not produced it will not activate protein kinase A. So further inhibition of glycolysis, glycogen synthesis will not occur. Activation of gluconeogenesis, glycogenolysis will not occur.So glucose will be contineously get utilized and when it will be less in body(during fasting) gluconeogenesis will not occur and blood glucose levels will be drastically low.

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