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Glucose-6-phosphate is the substrate for glucose-6-phosphatase, an enzyme found in the liver but not in the...

Glucose-6-phosphate is the substrate for glucose-6-phosphatase, an enzyme found in the liver but not in the muscles or brain.

(a) Why is the selective expression of this enzyme (liver vs muscle and brain) important to glucose metabolism in animals?

(b) Muscle glycogen phosphorylase is inhibited by high levels of glucose-6-phosphate. Briefly explain the rationale for this inhibition.

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