Question

Three Main Components of the Exracellular Matrix

Explain the function of the sub-categories under the 3 main components of the Extra-cellular Matrix with respect to the Extracellular cell matrix

1. Gel-like polysaccharide ground substance fills spaces in ECM GAGs: Proteoglycans:

2. Fibrous structural proteins

a. Collagen

b. Elastin

3. Adhesion proteins -link components within matrix and ECM to cell surfaces

a. Fibronectin:

b. Laminin: in basal lamina

Answer 1

The function of proteoglycans in the extracellular matrix: It helps to withstand compressional force through hydration and swelling pressure.

Collagen: Most abundant protein in the ECM/human body. It provides structural support to resident cells.

Elastin: Provides elasticity to tissues.

Fibronectin: It is a glycoprotein that connects cells to collagen. It also allows cells to move along the ECM.

Laminin: Found in the basal lamina. They form web-like networks that resist tensile forces.